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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HELQ
All Species:
7.88
Human Site:
S21
Identified Species:
17.33
UniProt:
Q8TDG4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TDG4
NP_598375.2
1101
124175
S21
L
P
K
R
N
R
P
S
L
G
C
I
F
G
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001104832
1101
124326
S21
L
P
K
R
N
R
P
S
L
G
C
I
F
V
A
Dog
Lupus familis
XP_544959
1072
121306
G21
V
R
Q
R
S
R
P
G
L
G
S
V
F
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q2VPA6
1069
119080
N21
V
R
K
R
N
R
G
N
L
E
N
L
R
A
S
Rat
Rattus norvegicus
NP_001014156
1065
118695
S21
L
R
K
R
N
R
R
S
L
E
S
L
G
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517710
972
107104
Chicken
Gallus gallus
XP_420565
1048
116823
S21
I
S
S
A
R
K
R
S
H
P
P
A
Q
P
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691411
1010
112859
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648178
1051
117314
E22
L
S
E
E
S
T
S
E
S
H
A
K
R
Q
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001022911
923
102951
Sea Urchin
Strong. purpuratus
XP_796097
1147
129034
D50
V
P
R
Q
M
T
L
D
L
T
Q
R
L
L
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.9
83.1
N.A.
75.1
75.3
N.A.
56.6
61.5
N.A.
54.7
N.A.
36.9
N.A.
32.7
40.7
Protein Similarity:
100
N.A.
98.7
90.2
N.A.
84.4
84.9
N.A.
68
74.3
N.A.
71.1
N.A.
56.9
N.A.
51.4
59.7
P-Site Identity:
100
N.A.
93.3
46.6
N.A.
33.3
53.3
N.A.
0
6.6
N.A.
0
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
N.A.
93.3
73.3
N.A.
60
60
N.A.
0
20
N.A.
0
N.A.
20
N.A.
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
0
0
0
10
10
0
28
37
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
10
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
10
0
0
0
10
0
19
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
28
0
0
% F
% Gly:
0
0
0
0
0
0
10
10
0
28
0
0
10
10
10
% G
% His:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
19
0
0
0
% I
% Lys:
0
0
37
0
0
10
0
0
0
0
0
10
0
0
0
% K
% Leu:
37
0
0
0
0
0
10
0
55
0
0
19
10
10
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
37
0
0
10
0
0
10
0
0
0
0
% N
% Pro:
0
28
0
0
0
0
28
0
0
10
10
0
0
10
0
% P
% Gln:
0
0
10
10
0
0
0
0
0
0
10
0
10
10
0
% Q
% Arg:
0
28
10
46
10
46
19
0
0
0
0
10
19
0
0
% R
% Ser:
0
19
10
0
19
0
10
37
10
0
19
0
0
0
10
% S
% Thr:
0
0
0
0
0
19
0
0
0
10
0
0
0
0
0
% T
% Val:
28
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _